Implementation science in pediatric oncology: A narrative review and future directions

Charles A. Phillips, Lamia P. Barakat, Brad H. Pollock, L. Charles Bailey, Rinad S. Beidas

Research output: Contribution to journalReview articlepeer-review


Implementation science (IS) has garnered attention within oncology, and most prior IS work has focused on adult, not pediatric, oncology. This narrative review broadly characterizes IS for pediatric oncology. It includes studies through 2020 using the following search terms in PubMed, Ovid Medline, and Cochrane: “implementation science,” “pediatric,” “childhood,” “cancer,” and “oncology.” Systematic review was not performed due to the limited number of heterogeneous studies. Of 216 articles initially reviewed, nine were selected as specific to IS and pediatric oncology. All nine examined oncologic supportive care, cancer prevention, or cancer control. The supportive care focus is potentially due to the presence of cooperative study groups such as the Children's Oncology Group, which efficiently drive cancer-directed therapy changes through clinical trials. Future IS within pediatric oncology should embrace this ecosystem and focus on cancer control interventions that benefit patients across multiple cancer types and patients treated outside cooperative group studies.

Original languageEnglish (US)
Article numbere29579
JournalPediatric Blood and Cancer
Issue number4
StatePublished - Apr 2022
Externally publishedYes


  • implementation science
  • pediatric cancer
  • pediatric oncology
  • supportive care

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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