Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis

Stanley C. Holt, Jeffrey Ebersole, Jeffrey Felton, Michael Brunsvold, Kenneth S. Kornman

Research output: Contribution to journalArticle

356 Scopus citations

Abstract

Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.

Original languageEnglish (US)
Pages (from-to)55-57
Number of pages3
JournalScience
Volume239
Issue number4835
DOIs
StatePublished - 1988

ASJC Scopus subject areas

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