Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

Z. Schwartz, C. H. Lohmann, J. Oefinger, L. F. Bonewald, D. D. Dean, B. D. Boyan

Research output: Contribution to journalReview articlepeer-review

241 Scopus citations

Abstract

This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalAdvances in dental research
Volume13
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.'. Together they form a unique fingerprint.

Cite this