Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

Z. Schwartz; C. H. Lohmann; J. Oefinger; L. F. Bonewald; D. D. Dean; B. D. Boyan

doi:10.1177/08959374990130011301

Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

Z. Schwartz, C. H. Lohmann, J. Oefinger, L. F. Bonewald, D. D. Dean, B. D. Boyan

Research output: Contribution to journal › Review article › peer-review

265 Scopus citations

Abstract

This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

Original language	English (US)
Pages (from-to)	38-48
Number of pages	11
Journal	Advances in dental research
Volume	13
DOIs	https://doi.org/10.1177/08959374990130011301
State	Published - Jun 1999

ASJC Scopus subject areas

General Medicine

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title = "Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.",

abstract = "This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.",

author = "Z. Schwartz and Lohmann, {C. H.} and J. Oefinger and Bonewald, {L. F.} and Dean, {D. D.} and Boyan, {B. D.}",

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AU - Schwartz, Z.

AU - Lohmann, C. H.

AU - Oefinger, J.

AU - Bonewald, L. F.

AU - Dean, D. D.

AU - Boyan, B. D.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1999/6

Y1 - 1999/6

N2 - This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

AB - This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

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JO - Advances in dental research

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Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

Abstract

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