Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase

Medicine & Life Sciences

• Antley-Bixler Syndrome Phenotype 100%
• Cytochrome P-450 CYP1A2 69%
• Xenobiotics 59%
• Flavin-Adenine Dinucleotide 54%
• Cytochrome P-450 Enzyme System 52%
• Oxidoreductases 49%
• methoxyresorufin-O-demethylase 24%
• 2-anthramine 23%
• 2-amino-3-methylimidazo(4,5-f)quinoline 23%
• Mutation 22%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 21%
• NADPH-Ferrihemoprotein Reductase 18%
• Cytochrome P-450 CYP1A1 17%
• Cytochromes c 14%
• Drug Interactions 13%
• Liver 6%
• Pharmaceutical Preparations 5%

Chemical Compounds

• Xenobiotic Agent 62%
• Cytochrome P450 57%
• Mutation 45%
• Pharmacological Metabolism 41%
• Quinoline 17%
• Cofactor 16%
• Cytochrome 15%
• Reduction 8%