Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice

G. Fernandes, M. Nair, K. Onoe, T. Tanaka, R. Floyd, R. A. Good

Research output: Contribution to journalArticle

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Abstract

Several immunologic features were analyzed in mice on a zinc-deficient diet [Zn(-)], in mice pair-fed a diet containing zinc [Zn(+)], in mice fed a Zn(+) diet ad lib, and in mice fed laboratory chow ad lib. When placed on a Zn(-)diet, 6- to 8-week-old A/Jax, C57BL/Ks, and CBA/H mice showed loss of body weight, low lymphoid tissue weight, and profound involution of the thymus within 4-8 weeks after initiation of the regimen. Approximately 50% of the mice on the Zn(-)diet developed severe acrodermatitis enteropathica (lesions on tail and paws) and diarrhea. Pair-fed mice on the Zn(+)diet did not show any of these symptoms. Mice on the Zn(-)diet showed the following immune deficiencies: (i) depressed plaque-forming cells against sheep erythrocytes after in vivo immunization; (ii) depressed T killer cell activity against EL-4 tumor cells after in vivo immunization; and (iii) low natural killer cell activity. However, antibody-dependent cell-mediated cytotoxicity against chicken erythrocytes was normal in the mice on the Zn(-)diet. Deficiency of T killer cell activity was not observed when immunization with EL-4 allogeneic lymphoma cells was carried out in vitro. Progessive loss of relative and absolute number of Thy 1.2+ cells and a proportionate relative increase in cells bearing Fc receptors was seen in spleen and lymph nodes of Zn(-) animals. It appears that zinc is an essential element for maintenance of normal T cell and other immuno functions in vivo.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number1
StatePublished - 1979
Externally publishedYes

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Cellular Immunity
Zinc
Diet
Immunization
Erythrocytes
Antibody-Dependent Cell Cytotoxicity
Inbred CBA Mouse
Fc Receptors
Lymphoid Tissue
Natural Killer Cells
Thymus Gland
Tail
Chickens
Diarrhea
Lymphoma
Sheep
Spleen
Lymph Nodes
Body Weight
Maintenance

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. / Fernandes, G.; Nair, M.; Onoe, K.; Tanaka, T.; Floyd, R.; Good, R. A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 1, 1979, p. 457-461.

Research output: Contribution to journalArticle

Fernandes, G. ; Nair, M. ; Onoe, K. ; Tanaka, T. ; Floyd, R. ; Good, R. A. / Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. In: Proceedings of the National Academy of Sciences of the United States of America. 1979 ; Vol. 76, No. 1. pp. 457-461.
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