Impaired Secretion of Triglycerides by the Liver; A Cause of Tetracycline-Induced Fatty Liver

Christopher H. Hansen, Laleah H. Pearson, Steven Schenker, Burton Combes

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The increments in plasma triglyceride levels observed after administration of Triton were consistently and significantly lower in tetracycline-injected rats, when hepatic tetracycline concentration was high, than in Triton-injected controls. These data are interpreted as indicating impaired release of hepatic triglyceride in tetracycline-injected animals. Hepatic triglyceride increased in tetracycline-injected rats and most of this could be accounted for by impaired release of liver triglyceride. This mechanism, possibly due to impaired synthesis of hepatic lipid acceptor protein, appears to be the major cause of tetracycline-induced fatty liver.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume128
Issue number1
DOIs
StatePublished - May 1968
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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