Impaired renal tubular potassium secretion in systemic lupus erythematosus

Ralph A Defronzo, C. R. Cooke, M. Goldberg, M. Cox, A. R. Myers, Z. S. Agus

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Two patients with long-standing systemic lupus erythematosus were found to have persistent hyperkalemia. The hyperkalemia could not be explained by renal insufficiency, oliguria, diminished distal sodium delivery, acidemia, or hemolysis. After sodium depletion, urinary aldosterone excretion and plasma aldosterone concentration rose appropriately. No increase in urinary potassium excretion or decrease in serum potassium concentration was noted after fludrocortisone acetate, furosemide, or acetazolamide plus sodium bicarbonate. We conclude that these patients have a primary defect in renal tubular potassium secretion that may be related to an immune complex interstitial nephritis.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalAnnals of Internal Medicine
Volume86
Issue number3
StatePublished - 1977
Externally publishedYes

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Systemic Lupus Erythematosus
Potassium
Hyperkalemia
Aldosterone
Kidney
Sodium
Oliguria
Interstitial Nephritis
Acetazolamide
Sodium Bicarbonate
Furosemide
Hemolysis
Antigen-Antibody Complex
Renal Insufficiency
Serum
fludrocortisone acetate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Defronzo, R. A., Cooke, C. R., Goldberg, M., Cox, M., Myers, A. R., & Agus, Z. S. (1977). Impaired renal tubular potassium secretion in systemic lupus erythematosus. Annals of Internal Medicine, 86(3), 268-271.

Impaired renal tubular potassium secretion in systemic lupus erythematosus. / Defronzo, Ralph A; Cooke, C. R.; Goldberg, M.; Cox, M.; Myers, A. R.; Agus, Z. S.

In: Annals of Internal Medicine, Vol. 86, No. 3, 1977, p. 268-271.

Research output: Contribution to journalArticle

Defronzo, RA, Cooke, CR, Goldberg, M, Cox, M, Myers, AR & Agus, ZS 1977, 'Impaired renal tubular potassium secretion in systemic lupus erythematosus', Annals of Internal Medicine, vol. 86, no. 3, pp. 268-271.
Defronzo, Ralph A ; Cooke, C. R. ; Goldberg, M. ; Cox, M. ; Myers, A. R. ; Agus, Z. S. / Impaired renal tubular potassium secretion in systemic lupus erythematosus. In: Annals of Internal Medicine. 1977 ; Vol. 86, No. 3. pp. 268-271.
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