Impaired renal D1-like and D2-like dopamine receptor interaction in the spontaneously hypertensive rat

Cecilia A. Ladines, Chunyu Zeng, Laureano D. Asico, Sun Xiaoguang, Felice Pocchiari, Claudio Semeraro, Joseph Pisegna, Stephen Wank, Ikuyo Yamaguchi, Gilbert M. Eisner, Pedro A. Jose

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


D1-like (D1, D5) and D2-like (D2, D3, D4) dopamine receptors interact in the kidney to produce a natriuresis and a diuresis. Disruption of D1 or D3 receptors in mice results in hypertension that is caused, in part, by a decreased ability to excrete an acute saline load. We studied D1-like and D2-like receptor interaction in anesthetized spontaneously hypertensive rats (SHR) by the intrarenal infusion of Z-1046 (a novel dopamine receptor agonist with rank order potency of D3≥D4>D2≥D5≥D 1). Z-1046 increased glomerular filtration rate (GFR), urine flow, and sodium excretion in normotensive Wistar-Kyoto rats but not in SHRs. The lack of responsiveness to Z-1046 in SHRs was not an epiphenomenon, because intrarenal cholecystokinin infusion increased GFR, urine flow, and sodium excretion to a similar extent in the two rat strains. We conclude that renal D1-like and D2-like receptor interaction is impaired in SHRs. The impaired D1-like and D2-like receptor interaction in SHRs is not caused by alterations in the coding sequence of the D3 receptor, the D2-like receptor expressed in rat renal tubules that has been shown to be involved in sodium transport. Because the diuretic and natriuretic effects of D1-like receptors are, in part, caused by an interaction with D2-like receptors, it is possible that the decreased Z-1046 action in SHRs is secondary to the renal D1-like receptor dysfunction in this rat strain.

Original languageEnglish (US)
Pages (from-to)R1071-R1078
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number4 50-4
StatePublished - 2001
Externally publishedYes


  • Cholecystokinin
  • D-like receptors
  • D-like receptors
  • Diuresis
  • Hypertension
  • Natriuresis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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