Impaired glucose tolerance: Do pharmacological therapies correct the underlying metabolic disturbance?

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7 Scopus citations


Lifestyle intervention prevents or delays the conversion from impaired glucose tolerance (IGT) to type 2 diabetes. However, many subjects fail to achieve and/or maintain long-term weight loss and to follow a regular exercise regimen may require pharmacologic therapy. Insulin resistance in liver, muscle and fat, along with impaired beta-cell function, plays a central role in the pathogenesis of type 2 diabetes. Insulin sensitising drugs, including metformin and the thiazolidinediones, have significantly reduced the conversion rate of IGT to type 2 diabetes in subjects in several large, well designed clinical trials. Insulin-sensitising drugs are likely to play an important role in future strategies for diabetes prevention.

Original languageEnglish (US)
Pages (from-to)S24-S40
JournalBritish Journal of Diabetes and Vascular Disease
Issue numberSUPPL. 1
StatePublished - Jan 1 2003


  • Beta-cell dysfunction
  • Impaired glucose tolerance
  • Insulin resistance
  • Metformin
  • Thiazolidinediones
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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