Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: The insulin resistance atherosclerosis study

Carlos Lorenzo, Sara Hartnett, Anthony J. Hanley, Marian J. Rewers, Lynne E. Wagenknecht, Andrew J. Karter, Steven M. Haffner

Research output: Contribution to journalArticle

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Abstract

Context: Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state. Objective: The authors examined lipoprotein composition in IGT and IFG. Design and Setting: Cross-sectional analysis of a large epidemiological study was done. Participants: The Insulin Resistance Atherosclerosis Study had a total of 1107 participants. Main measures: Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein composition by nuclear magnetic resonance spectroscopy. Results: Compared with normal glucose tolerance, apolipoprotein B (105.2 vs 99.8 mg/dL, P < .05) was high in isolated IFG, triglyceride (1.48 vs 1.16 mmol/L, P < .001) was high in isolated IGT, and high-density lipoprotein cholesterol was low in combined IFG/IGT (1.12 vs 1.26 mmol/L, P < .001). Nuclear magnetic resonance spectroscopy revealed additional changes: increased total low-density lipoprotein (LDL) particles (1190 vs 1096 nmol/L, P < .01) in isolated IFG; increased large very-low-density lipoprotein (3.61 vs2.47 nmol/L, P < .01) and small LDL subclass particles (665 vs 541 nmol/L, P < .05) and decreased large LDL subclass particles (447 vs 513 nmol/L, P < .01) in isolated IGT; and decreased large high-density lipoprotein subclass particles in combined IFG/IGT (4.24 vs 5.39 μmol/L, P < .001). Conclusions: Isolated IFG is characterized by increased apolipoprotein B and total LDL particles, whereas isolated IGT is associated with increased triglycerides, large very-low-density lipoprotein subclass particles, and structural remodeling of LDL particles. These results may help to explain differences in cardiovascular disease risk in the prediabetic state.

Original languageEnglish (US)
Pages (from-to)1622-1630
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number4
DOIs
StatePublished - Apr 2013

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Glucose Intolerance
Apolipoproteins
Lipoproteins
Insulin Resistance
Fasting
Atherosclerosis
Insulin
Glucose
LDL Lipoproteins
Prediabetic State
Apolipoproteins B
Magnetic Resonance Spectroscopy
VLDL Lipoproteins
HDL Lipoproteins
HDL Cholesterol
Nuclear magnetic resonance spectroscopy
Epidemiologic Studies
Triglycerides
Cardiovascular Diseases
Cross-Sectional Studies

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes : The insulin resistance atherosclerosis study. / Lorenzo, Carlos; Hartnett, Sara; Hanley, Anthony J.; Rewers, Marian J.; Wagenknecht, Lynne E.; Karter, Andrew J.; Haffner, Steven M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 4, 04.2013, p. 1622-1630.

Research output: Contribution to journalArticle

Lorenzo, Carlos ; Hartnett, Sara ; Hanley, Anthony J. ; Rewers, Marian J. ; Wagenknecht, Lynne E. ; Karter, Andrew J. ; Haffner, Steven M. / Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes : The insulin resistance atherosclerosis study. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 4. pp. 1622-1630.
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T1 - Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes

T2 - The insulin resistance atherosclerosis study

AU - Lorenzo, Carlos

AU - Hartnett, Sara

AU - Hanley, Anthony J.

AU - Rewers, Marian J.

AU - Wagenknecht, Lynne E.

AU - Karter, Andrew J.

AU - Haffner, Steven M.

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N2 - Context: Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state. Objective: The authors examined lipoprotein composition in IGT and IFG. Design and Setting: Cross-sectional analysis of a large epidemiological study was done. Participants: The Insulin Resistance Atherosclerosis Study had a total of 1107 participants. Main measures: Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein composition by nuclear magnetic resonance spectroscopy. Results: Compared with normal glucose tolerance, apolipoprotein B (105.2 vs 99.8 mg/dL, P < .05) was high in isolated IFG, triglyceride (1.48 vs 1.16 mmol/L, P < .001) was high in isolated IGT, and high-density lipoprotein cholesterol was low in combined IFG/IGT (1.12 vs 1.26 mmol/L, P < .001). Nuclear magnetic resonance spectroscopy revealed additional changes: increased total low-density lipoprotein (LDL) particles (1190 vs 1096 nmol/L, P < .01) in isolated IFG; increased large very-low-density lipoprotein (3.61 vs2.47 nmol/L, P < .01) and small LDL subclass particles (665 vs 541 nmol/L, P < .05) and decreased large LDL subclass particles (447 vs 513 nmol/L, P < .01) in isolated IGT; and decreased large high-density lipoprotein subclass particles in combined IFG/IGT (4.24 vs 5.39 μmol/L, P < .001). Conclusions: Isolated IFG is characterized by increased apolipoprotein B and total LDL particles, whereas isolated IGT is associated with increased triglycerides, large very-low-density lipoprotein subclass particles, and structural remodeling of LDL particles. These results may help to explain differences in cardiovascular disease risk in the prediabetic state.

AB - Context: Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state. Objective: The authors examined lipoprotein composition in IGT and IFG. Design and Setting: Cross-sectional analysis of a large epidemiological study was done. Participants: The Insulin Resistance Atherosclerosis Study had a total of 1107 participants. Main measures: Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein composition by nuclear magnetic resonance spectroscopy. Results: Compared with normal glucose tolerance, apolipoprotein B (105.2 vs 99.8 mg/dL, P < .05) was high in isolated IFG, triglyceride (1.48 vs 1.16 mmol/L, P < .001) was high in isolated IGT, and high-density lipoprotein cholesterol was low in combined IFG/IGT (1.12 vs 1.26 mmol/L, P < .001). Nuclear magnetic resonance spectroscopy revealed additional changes: increased total low-density lipoprotein (LDL) particles (1190 vs 1096 nmol/L, P < .01) in isolated IFG; increased large very-low-density lipoprotein (3.61 vs2.47 nmol/L, P < .01) and small LDL subclass particles (665 vs 541 nmol/L, P < .05) and decreased large LDL subclass particles (447 vs 513 nmol/L, P < .01) in isolated IGT; and decreased large high-density lipoprotein subclass particles in combined IFG/IGT (4.24 vs 5.39 μmol/L, P < .001). Conclusions: Isolated IFG is characterized by increased apolipoprotein B and total LDL particles, whereas isolated IGT is associated with increased triglycerides, large very-low-density lipoprotein subclass particles, and structural remodeling of LDL particles. These results may help to explain differences in cardiovascular disease risk in the prediabetic state.

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