Impaired elimination of caffeine by oral contraceptive steroids

Rashmi V. Patwardhan, Paul V. Desmond, Raymond F. Johnson, Steven Schenker

Research output: Contribution to journalArticlepeer-review

147 Scopus citations


The effect of OCS on the disposition and elimination of caffeine was examined. Caffeine (250 mg) was administered orally to 13 healthy males, nine healthy females taking no OCS, and nine healthy females on OCS. The t 1 2(β) was significantly prolonged in women on OCS (10.7 ± 3.0 hr vs. 6.2 ± 1.6) (p < 0.001) as compared to women taking no OCS. Women on OCS had a significantly lower total plasma clearance (0.79 ± 0.21 ml/min/kg vs. 1.3 ± 0.35) and free clearance (1.12 ± 0.28 ml/min/kg vs. 1.97 ± 0.57) than women not taking OCS. Volumes of distribution and plasma binding were similar in both groups of females. When women taking no OCS were compared with men, all pharmacokinetic parameters were similar except for volume of distribution, which was significantly larger in the women (p < 0.05). We conclude that OCS impair the elimination of caffeine.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Issue number4
StatePublished - Apr 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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