Impacts of transcriptional regulation on aging and senescence

Arun K. Roy, Thomas Oh, Omar Rivera, James Mubiru, Chung S. Song, Bandana Chatterjee

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

The genetic makeup of the organism appears to dictate the species-specific rate of aging and the maximum life-span potential. The genotype is converted to phenotype through transcriptional and translational regulation. A group of gene regulatory proteins (transcription factors) play critical roles in controlling the rates of transcription of specific genes by directly interacting with regulatory sequences at gene promoters. Here, we review the basic mechanism of transcriptional control and the role of a number of transcription factors whose level and/or activity alter with age. Among these age-dependent transcription factors, many are involved in the regulation of stress and inflammatory responses and are subjected to functional alterations by reactive oxygen species (ROSs). A progressive rise of oxidative stress, impaired ability to cope with stressful stimuli and prolongation of the inflammatory response are some of the hallmarks of the senescent phenotype. Results published to date are supportive of the concept that a species-specific program of the temporal regulation of genes with additional modulation by a number of epigenetic factors, mediates the age-dependent deterioration of physiological functions and development of the senescent phenotype.

Original languageEnglish (US)
Pages (from-to)367-380
Number of pages14
JournalAgeing Research Reviews
Volume1
Issue number3
DOIs
StatePublished - Jun 1 2002

Keywords

  • Aging
  • Gene regulation
  • Reactive oxygen species
  • Senescence phenotype
  • Transcription factors

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Fingerprint Dive into the research topics of 'Impacts of transcriptional regulation on aging and senescence'. Together they form a unique fingerprint.

  • Cite this