Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

Fern Anari, Chethan Ramamurthy, Matthew Zibelman

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.

Original languageEnglish (US)
Pages (from-to)1409-1421
Number of pages13
JournalFuture Oncology
Volume14
Issue number14
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • biomarkers
  • immunotherapy
  • molecular oncology
  • oncogenes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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