Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

Fern Anari; Chethan Ramamurthy; Matthew Zibelman

doi:10.2217/fon-2017-0585

Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

Fern Anari, Chethan Ramamurthy, Matthew Zibelman

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.

Original language	English (US)
Pages (from-to)	1409-1421
Number of pages	13
Journal	Future Oncology
Volume	14
Issue number	14
DOIs	https://doi.org/10.2217/fon-2017-0585
State	Published - Jun 2018
Externally published	Yes

Keywords

biomarkers
immunotherapy
molecular oncology
oncogenes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer",

abstract = "The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.",

keywords = "biomarkers, immunotherapy, molecular oncology, oncogenes",

author = "Fern Anari and Chethan Ramamurthy and Matthew Zibelman",

note = "Funding Information: M Zibelman receives institution-directed research funding from Horizon Pharma and Bristol-Myers Squibb. He has participated in advisory boards for EMD-Serono and Pfizer. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2018",

month = jun,

doi = "10.2217/fon-2017-0585",

language = "English (US)",

volume = "14",

pages = "1409--1421",

journal = "Future Oncology",

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AU - Anari, Fern

AU - Ramamurthy, Chethan

AU - Zibelman, Matthew

N1 - Funding Information: M Zibelman receives institution-directed research funding from Horizon Pharma and Bristol-Myers Squibb. He has participated in advisory boards for EMD-Serono and Pfizer. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2018 Future Medicine Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2018/6

Y1 - 2018/6

N2 - The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.

AB - The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.

KW - biomarkers

KW - immunotherapy

KW - molecular oncology

KW - oncogenes

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SN - 1479-6694

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ER -

Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

Abstract

Keywords

ASJC Scopus subject areas

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