Impact of stress on prefrontal glutamatergic, monoaminergic and cannabinoid systems

M. Danet Lapiz-Bluhm

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Stress has been shown to have marked and divergent effects on learning and memory which involves specific brain regions, such as spatial and declarative memory involving the hippocampus, memory of emotional arousing experiences and fear involving the amygdala, and executive functions and fear extinction involving the prefrontal cortex or the PFC. Response to stress involves a coordinated activation of a constellation of physiological systems including the activation of the hypothalamic-pituitary-adrenal (HPA) axis and other modulatory neurotransmitters and signaling systems. This paper presents a concise review of the effects of stress and glucocorticoids on the glutamatergic and monoaminergic (including noradrenergic, dopaminergic, and serotonergic systems) neurotransmitter systems as well as endocannabinoid signaling. Because of the breadth of the scope of this topic, the review is limited to the effects of stress on these brain systems on the prefrontal cortex, and where relevant, the hippocampus and the amygdala.

    Original languageEnglish (US)
    Pages (from-to)45-66
    Number of pages22
    JournalCurrent Topics in Behavioral Neurosciences
    Volume18
    DOIs
    StatePublished - 2014

    Fingerprint

    Cannabinoids
    Amygdala
    Prefrontal Cortex
    Fear
    Neurotransmitter Agents
    Hippocampus
    Endocannabinoids
    Executive Function
    Brain
    Glucocorticoids
    Learning
    Spatial Memory
    Psychological Extinction

    Keywords

    • Dopaminergic
    • Endocannabinoid
    • Glucocorticoids
    • Glutamatergic
    • Noradrenergic
    • Serotonergic
    • Stress

    ASJC Scopus subject areas

    • Behavioral Neuroscience

    Cite this

    Impact of stress on prefrontal glutamatergic, monoaminergic and cannabinoid systems. / Lapiz-Bluhm, M. Danet.

    In: Current Topics in Behavioral Neurosciences, Vol. 18, 2014, p. 45-66.

    Research output: Contribution to journalArticle

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