Impact of risperidone versus haloperidol on activities of daily living in the treatment of refractory schizophrenia

Robert Paul Liberman, Daniel Gutkind, Jim Mintz, Michael Green, B. D. Marshall, Mary Jane Robertson, Jeffery Hayden

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Risperidone has been shown to improve verbal working memory, executive functioning, attention, reaction time, and verbal learning, which, in turn, have been associated with improved functional outcomes. We tested whether risperidone was associated with greater improvements than haloperidol in activities of daily living (ADLs) among persons having treatment-refractory schizophrenia. In a double-blind, controlled trial of fixed and flexible doses of haloperidol and risperidone, changes in ADLs were operationally monitored on a behavior therapy unit of a state hospital. While no differential effects were noted between risperidone and haloperidol in ADLS, these self-care skills significantly improved as subjects spent longer times on the behavior therapy unit. Working memory and verbal learning did correlate with improvements in ADLs, independent of drug condition. The contingencies of reinforcement and specific training programs on the behavior therapy unit may have been prepotent for the learning of ADLs, obscuring any differential impact of risperidone. Moreover, ADLs may be governed more by "procedural" learning than by working memory or verbal learning, with the former not differentially influenced by typical verus atypical antipsychotics.

Original languageEnglish (US)
Pages (from-to)469-473
Number of pages5
JournalComprehensive Psychiatry
Volume43
Issue number6
DOIs
StatePublished - Nov 2002
Externally publishedYes

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Risperidone
Haloperidol
Activities of Daily Living
Schizophrenia
Verbal Learning
Behavior Therapy
Short-Term Memory
Learning
Therapeutics
State Hospitals
Self Care
Antipsychotic Agents
Reaction Time
Education
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Impact of risperidone versus haloperidol on activities of daily living in the treatment of refractory schizophrenia. / Liberman, Robert Paul; Gutkind, Daniel; Mintz, Jim; Green, Michael; Marshall, B. D.; Robertson, Mary Jane; Hayden, Jeffery.

In: Comprehensive Psychiatry, Vol. 43, No. 6, 11.2002, p. 469-473.

Research output: Contribution to journalArticle

Liberman, Robert Paul ; Gutkind, Daniel ; Mintz, Jim ; Green, Michael ; Marshall, B. D. ; Robertson, Mary Jane ; Hayden, Jeffery. / Impact of risperidone versus haloperidol on activities of daily living in the treatment of refractory schizophrenia. In: Comprehensive Psychiatry. 2002 ; Vol. 43, No. 6. pp. 469-473.
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