TY - JOUR
T1 - Impact of recombinant platelet-derived growth factor BB on bone regeneration
T2 - A study in rabbits
AU - Thoma, Daniel S.
AU - Jung, Ronald E.
AU - Hänseler, Patrick
AU - Hämmerle, Christoph H.F.
AU - Cochran, David L.
AU - Weber, Franz E.
PY - 2012
Y1 - 2012
N2 - The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with β-tricalcium phosphate (β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits’ calvaria and randomly allocated to one of four groups: (1) empty, (2) β-TCP, (3) β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (β-TCP), 37.1% ± 8.9% (β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.
AB - The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with β-tricalcium phosphate (β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits’ calvaria and randomly allocated to one of four groups: (1) empty, (2) β-TCP, (3) β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (β-TCP), 37.1% ± 8.9% (β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.
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M3 - Article
C2 - 22292149
AN - SCOPUS:84864022018
SN - 0198-7569
VL - 32
SP - 195
EP - 202
JO - International Journal of Periodontics and Restorative Dentistry
JF - International Journal of Periodontics and Restorative Dentistry
IS - 2
ER -