Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia

Elson Asevedo, Ary Gadelha, Cristiano Noto, Rodrigo B. Mansur, André Zugman, Síntia I.N. Belangero, Arthur A. Berberian, Bruno S. Scarpato, Emilie Leclerc, Ant Ônio L. Teixeira, Clarissa S. Gama, Rodrigo A. Bressan, Elisa Brietzke

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Objective: To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the correlation of these biomarkers with cognitive performance. Methods: Thirty individuals with SZ and 27 healthy controls were included and the following plasmatic biomarkers' levels were determined according to manufacturers' instructions: BDNF, TBARS, protein carbonyl content (PCC) and the chemokines CXCL-10/IP-10, CXCL-8/IL-8, CCL-11, CCL-24/Eotaxin-2, CCL-2/MCP-1, CCL-3/MIP-1. Selected neuropsychological tasks were administered to assess verbal learning (Hopkins Verbal Learning Test), verbal fluency (FAS test), working memory (Visual Working Memory Task, Keep Track Task, Letter Memory Task), set shifting (Plus-minus task, Number-letter task), inhibition (Computerized Stroop Task, Semantic Generation Task) and complex executive function tasks (Tower of London and the shortened version of the WCST-64). Results: Compared with the healthy control group, individuals with SZ presented significantly higher levels of BDNF and the chemokine CCL-11, and lower levels of TBARS and the chemokine CXCL-10/IP-10. When we examined only the SZ group, BDNF levels were positively correlated with semantic generation tasks. Working memory ability was negatively correlated with PCC. Regarding chemokines, CCL-11 was negatively correlated to performance in working memory test, and positively correlated with cognitive flexibility task. CXCL-8/IL-8 was positively correlated with verbal fluency. CCL-24/Eotaxin-2 was positively correlated with semantic generation ability and letter memory task. Conclusions: Our results indicate that cognitive performance in SZ is associated with mediators of neuroplasticity that can be measured peripherally.

Original languageEnglish (US)
Pages (from-to)1376-1382
Number of pages7
JournalJournal of Psychiatric Research
Volume47
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • BDNF
  • Biomarkers
  • Chemokines
  • Cognition
  • Oxidative stress
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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