Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder

Charles L. Bowden, Joseph R. Calabrese, Terence A. Ketter, Gary S. Sachs, Robin L. White, Thomas R. Thompson

Research output: Contribution to journalArticle

Abstract

Objective: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. Method: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. Results: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N= 399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. Conclusions: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.

Original languageEnglish (US)
Pages (from-to)1199-1201
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number7
DOIs
StatePublished - Jul 2006

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Bipolar Disorder
Lithium
Weights and Measures
Placebos
lamotrigine
Body Weight
Maintenance

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bowden, C. L., Calabrese, J. R., Ketter, T. A., Sachs, G. S., White, R. L., & Thompson, T. R. (2006). Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. American Journal of Psychiatry, 163(7), 1199-1201. https://doi.org/10.1176/appi.ajp.163.7.1199

Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. / Bowden, Charles L.; Calabrese, Joseph R.; Ketter, Terence A.; Sachs, Gary S.; White, Robin L.; Thompson, Thomas R.

In: American Journal of Psychiatry, Vol. 163, No. 7, 07.2006, p. 1199-1201.

Research output: Contribution to journalArticle

Bowden, CL, Calabrese, JR, Ketter, TA, Sachs, GS, White, RL & Thompson, TR 2006, 'Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder', American Journal of Psychiatry, vol. 163, no. 7, pp. 1199-1201. https://doi.org/10.1176/appi.ajp.163.7.1199
Bowden, Charles L. ; Calabrese, Joseph R. ; Ketter, Terence A. ; Sachs, Gary S. ; White, Robin L. ; Thompson, Thomas R. / Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. In: American Journal of Psychiatry. 2006 ; Vol. 163, No. 7. pp. 1199-1201.
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