Abstract
Objective: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. Method: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. Results: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N= 399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. Conclusions: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1199-1201 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 163 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2006 |
Fingerprint
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. / Bowden, Charles L.; Calabrese, Joseph R.; Ketter, Terence A.; Sachs, Gary S.; White, Robin L.; Thompson, Thomas R.
In: American Journal of Psychiatry, Vol. 163, No. 7, 07.2006, p. 1199-1201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder
AU - Bowden, Charles L.
AU - Calabrese, Joseph R.
AU - Ketter, Terence A.
AU - Sachs, Gary S.
AU - White, Robin L.
AU - Thompson, Thomas R.
PY - 2006/7
Y1 - 2006/7
N2 - Objective: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. Method: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. Results: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N= 399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. Conclusions: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.
AB - Objective: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. Method: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. Results: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N= 399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. Conclusions: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.
UR - http://www.scopus.com/inward/record.url?scp=33746891920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746891920&partnerID=8YFLogxK
U2 - 10.1176/appi.ajp.163.7.1199
DO - 10.1176/appi.ajp.163.7.1199
M3 - Article
C2 - 16816224
VL - 163
SP - 1199
EP - 1201
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 7
ER -