Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder

Charles L. Bowden, Joseph R. Calabrese, Terence A. Ketter, Gary S. Sachs, Robin L. White, Thomas R. Thompson

Research output: Contribution to journalArticle

Abstract

Objective: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. Method: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. Results: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N= 399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. Conclusions: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.

Original languageEnglish (US)
Pages (from-to)1199-1201
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Bowden, C. L., Calabrese, J. R., Ketter, T. A., Sachs, G. S., White, R. L., & Thompson, T. R. (2006). Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. American Journal of Psychiatry, 163(7), 1199-1201. https://doi.org/10.1176/appi.ajp.163.7.1199