Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

Mirjam V. Faulenbach, Lorena A. Wright, Carlos Lorenzo, Kristina M. Utzschneider, Julia H. Goedecke, Wilfred Y. Fujimoto, Edward J. Boyko, Marguerite J. McNeely, Donna L. Leonetti, Steven M. Haffner, Steven E. Kahn

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective: To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. Materials and Methods: Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria. Results: In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p = 0.9) and no subject had a repeat negative insulinogenic index. Conclusions: A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalJournal of Diabetes and its Complications
Volume27
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • Diabetes
  • Glucose
  • Impaired glucose tolerance
  • Insulin
  • Insulinogenic index
  • Oral glucose tolerance test

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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