Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

Mirjam V. Faulenbach; Lorena A. Wright; Carlos Lorenzo; Kristina M. Utzschneider; Julia H. Goedecke; Wilfred Y. Fujimoto; Edward J. Boyko; Marguerite J. McNeely; Donna L. Leonetti; Steven M. Haffner; Steven E. Kahn

doi:10.1016/j.jdiacomp.2012.09.011

Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

Mirjam V. Faulenbach, Lorena A. Wright, Carlos Lorenzo, Kristina M. Utzschneider, Julia H. Goedecke, Wilfred Y. Fujimoto, Edward J. Boyko, Marguerite J. McNeely, Donna L. Leonetti, Steven M. Haffner, Steven E. Kahn

Division of Rheumatology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objective: To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. Materials and Methods: Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria. Results: In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p = 0.9) and no subject had a repeat negative insulinogenic index. Conclusions: A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.

Original language	English (US)
Pages (from-to)	158-161
Number of pages	4
Journal	Journal of Diabetes and Its Complications
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.jdiacomp.2012.09.011
State	Published - Mar 2013

Keywords

Diabetes
Glucose
Impaired glucose tolerance
Insulin
Insulinogenic index
Oral glucose tolerance test

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.jdiacomp.2012.09.011

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Faulenbach, M. V., Wright, L. A., Lorenzo, C., Utzschneider, K. M., Goedecke, J. H., Fujimoto, W. Y., Boyko, E. J., McNeely, M. J., Leonetti, D. L., Haffner, S. M., & Kahn, S. E. (2013). Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index. Journal of Diabetes and Its Complications, 27(2), 158-161. https://doi.org/10.1016/j.jdiacomp.2012.09.011

@article{901e42630ef04ae0b7932bc65499b7ec,

title = "Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index",

abstract = "Objective: To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. Materials and Methods: Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria. Results: In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p = 0.9) and no subject had a repeat negative insulinogenic index. Conclusions: A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.",

keywords = "Diabetes, Glucose, Impaired glucose tolerance, Insulin, Insulinogenic index, Oral glucose tolerance test",

author = "Faulenbach, {Mirjam V.} and Wright, {Lorena A.} and Carlos Lorenzo and Utzschneider, {Kristina M.} and Goedecke, {Julia H.} and Fujimoto, {Wilfred Y.} and Boyko, {Edward J.} and McNeely, {Marguerite J.} and Leonetti, {Donna L.} and Haffner, {Steven M.} and Kahn, {Steven E.}",

note = "Funding Information: We thank the study participants who made this analysis possible. The study was supported in part by the Department of Veterans Affairs , NIH grants, DK-002654, DK-007247, DK-017047, DK-031170, DK-035816, HL-049293 and RR-000037 in Seattle, HL-24799 and HL-36820 in San Antonio, and the American Diabetes Association . MVF was supported by the Swiss National Foundation grant PBZHB-116877 .",

year = "2013",

month = mar,

doi = "10.1016/j.jdiacomp.2012.09.011",

language = "English (US)",

volume = "27",

pages = "158--161",

journal = "Journal of Diabetes and Its Complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

AU - Faulenbach, Mirjam V.

AU - Wright, Lorena A.

AU - Lorenzo, Carlos

AU - Utzschneider, Kristina M.

AU - Goedecke, Julia H.

AU - Fujimoto, Wilfred Y.

AU - Boyko, Edward J.

AU - McNeely, Marguerite J.

AU - Leonetti, Donna L.

AU - Haffner, Steven M.

AU - Kahn, Steven E.

N1 - Funding Information: We thank the study participants who made this analysis possible. The study was supported in part by the Department of Veterans Affairs , NIH grants, DK-002654, DK-007247, DK-017047, DK-031170, DK-035816, HL-049293 and RR-000037 in Seattle, HL-24799 and HL-36820 in San Antonio, and the American Diabetes Association . MVF was supported by the Swiss National Foundation grant PBZHB-116877 .

PY - 2013/3

Y1 - 2013/3

N2 - Objective: To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. Materials and Methods: Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria. Results: In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p = 0.9) and no subject had a repeat negative insulinogenic index. Conclusions: A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.

AB - Objective: To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. Materials and Methods: Data from the San Antonio Heart Study (n = 2494), Japanese American Community Diabetes Study (JACDS; n = 594) and Genetics of NIDDM Study (n = 1519) were examined. Glucose tolerance was defined by ADA criteria. Results: In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p < 0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p = 0.9) and no subject had a repeat negative insulinogenic index. Conclusions: A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.

KW - Diabetes

KW - Glucose

KW - Impaired glucose tolerance

KW - Insulin

KW - Insulinogenic index

KW - Oral glucose tolerance test

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U2 - 10.1016/j.jdiacomp.2012.09.011

DO - 10.1016/j.jdiacomp.2012.09.011

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AN - SCOPUS:84875215428

SN - 1056-8727

VL - 27

SP - 158

EP - 161

JO - Journal of Diabetes and Its Complications

JF - Journal of Diabetes and Its Complications

IS - 2

ER -

Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index

Abstract

Keywords

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