Impact of day 3 or day 5 embryo transfer on pregnancy rates and multiple gestations

Ronald Beesley, Randal D Robinson, Anthony Propst, Nancy Arthur, Matthew Retzloff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To test the hypothesis that day 5 ET (D5ET) is superior to day 3 ET (D3ET) in pregnancy outcome and that it also reduces multiple gestations. Design: Retrospective cohort study. Setting: Assisted reproductive technologies program at Wilford Hall Medical Center. Patient(s): Patients electing for either D3ET or D5ET. Intervention(s): Participants meeting inclusion criteria for D5ET elected either D3ET or D5ET. Main Outcome Measure(s): Cycles were compared by day of transfer and further stratified by patient age (<35 years and 35-40 years). The number of oocytes retrieved, embryos on day 3, embryos transferred, pregnancy rate, implantation rate, and twin and high order multiples (≥triplets) rates were compared. Result(s): Of the 274 patients who met our inclusion criteria, 153 underwent a D3ET and 121 underwent a D5ET. The D5ET group had a significantly lower mean age and number of embryos transferred and a higher implantation rate (56% vs. 42%) than the D3ET group. Patients who were 35-40 years old had a significantly higher live-birth rate (68% vs. 40%). Although not statistically significant, the D5ET groups had higher clinical pregnancy (73% vs. 65%) and twin pregnancy (33% vs. 25%) rates. Conclusion(s): Blastocyst transfer resulted in fewer embryos transferred, with a trend toward improved clinical pregnancy and higher twin pregnancy rates. Live-birth rates were improved in patients 35-40 years of age. Younger patients opting for D5ET should do so with a commitment toward single ET.

Original languageEnglish (US)
Pages (from-to)1717-1720
Number of pages4
JournalFertility and Sterility
Volume91
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

Fingerprint

Embryo Transfer
Pregnancy Rate
Pregnancy
Embryonic Structures
Twin Pregnancy
Birth Rate
Live Birth
Assisted Reproductive Techniques
Pregnancy Outcome
Oocytes
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)

Keywords

  • blastocyst transfer
  • Embryo transfer
  • multiple gestation

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Impact of day 3 or day 5 embryo transfer on pregnancy rates and multiple gestations. / Beesley, Ronald; Robinson, Randal D; Propst, Anthony; Arthur, Nancy; Retzloff, Matthew.

In: Fertility and Sterility, Vol. 91, No. 5, 05.2009, p. 1717-1720.

Research output: Contribution to journalArticle

Beesley, R, Robinson, RD, Propst, A, Arthur, N & Retzloff, M 2009, 'Impact of day 3 or day 5 embryo transfer on pregnancy rates and multiple gestations', Fertility and Sterility, vol. 91, no. 5, pp. 1717-1720. https://doi.org/10.1016/j.fertnstert.2008.02.003
Beesley, Ronald ; Robinson, Randal D ; Propst, Anthony ; Arthur, Nancy ; Retzloff, Matthew. / Impact of day 3 or day 5 embryo transfer on pregnancy rates and multiple gestations. In: Fertility and Sterility. 2009 ; Vol. 91, No. 5. pp. 1717-1720.
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