Impact of Affect on Lung Transplant Candidate Outcomes

Kelly M. Pennington, Roberto P. Benzo, Terry D. Schneekloth, Marie Budev, Satish Chandrashekaran, David B. Erasmus, Erika D. Lease, Deborah J. Levine, Karin Thompson, Elizabeth Stevens, Paul J. Novotny, Cassie C. Kennedy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: We examined the association of adult lung transplant candidates’ self-reported affect with transplant-related outcomes, evaluating whether a positive (vs negative) frame of mind might be protective. Method: Consenting waitlisted candidates from 6 centers completed the questionnaires including the Positive and Negative Affect Schedule annually and posttransplant. Univariate logistic regression analysis was performed to determine the association of baseline affect with outcomes of death or delisting. Models were subsequently adjusted for age, marital status, and education. Results: Questionnaires were completed by 169 candidates (77.9% participation). Mean positive affect, negative affect, and positive-to-negative affect ratio (positivity ratio) were similar to expected norms. The scores of the questionnaire did not change significantly over time. Fifteen (8.9%) waitlisted participants died. Candidates who died while waiting had lower positivity ratios compared to those who survived (1.82 vs 2.45; P =.02). A more negative affect was associated with increased death on the waiting list (adjusted odds ratio [OR] 1.10; P =.021). Conversely, a higher positivity ratio was associated with decreased death while waiting (adjusted OR: 0.45; P =.027). Conclusion: Negative affect may represent a novel risk factor for death on the waitlist. Enhancing positive affect may represent a useful target for psychological optimization in lung transplant candidates.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalProgress in Transplantation
Volume30
Issue number1
DOIs
StatePublished - Mar 1 2020

Keywords

  • affect
  • emotional well-being
  • lung transplant
  • positive and negative affect schedule (PANAS)
  • transplant waiting list

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Pennington, K. M., Benzo, R. P., Schneekloth, T. D., Budev, M., Chandrashekaran, S., Erasmus, D. B., Lease, E. D., Levine, D. J., Thompson, K., Stevens, E., Novotny, P. J., & Kennedy, C. C. (2020). Impact of Affect on Lung Transplant Candidate Outcomes. Progress in Transplantation, 30(1), 13-21. https://doi.org/10.1177/1526924819892921