Immunotoxins: A new approach to cancer therapy

Ellen S. Vitetta, Keith A. Krolick, Muneo Miyama-Inaba, William Cushley, Jonathan W. Uhr

Research output: Contribution to journalReview articlepeer-review

213 Scopus citations


Conjugates of tumor-reactive antibody and toxins (immunotoxins) have been used to eradicate tumor cells in vitro and in vivo. Such immunotoxins are highly effective in killing murine leukemic cells in infiltrated bone marrow and should be useful in the bone marrow rescue approach for the treatment of cancer. Similar immunotoxins injected parentally can help to induce prolonged remissions in leukemic mice, and antigen-containing immunotoxins can induce immunologic unresponsiveness in vitro in normal murine splenocytes. Thus, long-range goals for the parental use of immunotoxins include the killing of cancer cells in vivo and the modulation of the immune response for therapeutic purposes.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
Issue number4585
StatePublished - 1983

ASJC Scopus subject areas

  • General


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