Immunosuppressive Effects of Human CTLA4Ig in a Non-Human Primate Model of Allogeneic Pancreatic Islet Transplantation

Matteo G. Levisetti, Philip A. Padrid, Gregory L. Szot, Naveen Mittal, Shone M. Meehan, Craig L. Wardrip, Gary S. Gray, David S. Bruce, J. R. Thistlethwaite, Jeffrey A. Bluestone

Research output: Contribution to journalArticlepeer-review

233 Scopus citations

Abstract

Ag-specific T cell activation requires a CD28-mediated co-stimulatory interaction. This observation has suggested novel approaches to suppress donor-specific immunity, including the use of soluble CD28 antagonists, such as CTLA4Ig, which suppresses transplant rejection in small animal models. In this study, CTLA4Ig therapy was examined in a non-human primate model of allogeneic pancreatic islet transplantation. Two of five CTLA4Ig-treated monkeys showed prolonged graft survival, which correlated with donor-specific hyporesponsiveness in vitro. Humoral responses to the transplanted tissue were suppressed in all treated animals. These results suggest that CTLA4Ig is effective in suppressing both humoral and cellular immune responses in a non-human primate model of allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)5187-5191
Number of pages5
JournalJournal of Immunology
Volume159
Issue number11
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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