Immunopathological response to severe injury: Platelet activation and the Th-17 immune response

Rachel S. Morris, Beverley S. Schaffer, Jonathan B. Lundy, Heather F. Pidcoke, Kevin K. Chung, Daniel N. Darlington, Andrew P. Cap, Martin G Schwacha

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Alterations in coagulation, inflammation and immunity are associated with major injury. As platelets have both coagulation and immune functions, the aim of this study is to correlate platelet activation with the immunoinflammatory response in trauma and burn patients. Blood samples were drawn from trauma and burn patients and healthy volunteers. Platelet (sCD40L) and coagulation (D-dimers) activation, cytokines and inflammatory markers were assessed. sCD40L, D-dimers and cytokines were elevated in both injury groups. Overall, sCD40L levels correlated with interleukin (IL)-6 and tumour necrosis factor-Alpha. Subanalysis revealed a correlation between sCD40L and IL-17a in the healthy volunteers and burn groups, but not the trauma group. A parallel activation of platelets and the inflammatory response occurs postinjury. However, in trauma patients, a potential critical interrelationship between platelet activation and the Th-17 response appears to be lacking, which may contribute to coagulopathic and immunoinflammatory complications and warrants further study.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalBlood Coagulation and Fibrinolysis
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Coagulation
  • Cytokines
  • IL-17a
  • SCD40L

ASJC Scopus subject areas

  • Hematology

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