Immunometabolic alterations in lupus: where do they come from and where do we go from there?

Longhuan Ma, Tracoyia Roach, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the overactivation of the immune system has been associated with metabolic alterations. Targeting the altered immunometabolism has been proposed to treat SLE patients based on their results obtained and mouse models of the disease. Here, we review the recent literature to discuss the possible origins of the alterations in the metabolism of immune cells in lupus, the dominant role of mitochondrial defects, technological advances that may move the field forward, as well as how targeting lupus immunometabolism may have therapeutic potential.

Original languageEnglish (US)
Article number102245
JournalCurrent Opinion in Immunology
Volume78
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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