Immunological Tests and Their Interpretation in Uveitis

S. R. Rathinam, Ilknur Tugal-Tutkun, Mamta Agarwal, Vedhanayaki Rajesh, Merih Egriparmak, Gazal Patnaik

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Uveitis is a complex disorder including both infectious and non-infectious etiologies. Clinical diagnosis is a challenge because many diseases share common clinical signs. Laboratory support is crucial for confirming the clinical diagnosis. Laboratory diagnosis includes direct tests and indirect tests. For example smear, culture, and molecular diagnostics demonstrate the pathogens, hence they are direct tests. Immunologic tests employ an antigen to detect presence of antibodies to a pathogen, or an antibody to detect the presence of an antigen, of the pathogen in the specimens. The immunological tests used in laboratories are made by producing artificial antibodies that exactly 'match' the pathogen in question. When these antibodies come into contact with a sample they bind to the matching pathogen if found in the sample. Hence they are grouped under indirect evidence. There are several investigations in uveitis to reach the confirmed diagnosis including microbiological, immunological, imaging and molecular diagnostic testing. In this section we will discuss immunological investigations of infectious and non-infectious uveitis.

Original languageEnglish (US)
Pages (from-to)1737-1748
Number of pages12
JournalIndian Journal of Ophthalmology
Issue number9
StatePublished - Sep 2020
Externally publishedYes


  • Infectious
  • investigations
  • non-infectious
  • novel infections
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology


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