TY - JOUR
T1 - Immunological Status of aged subjects with reference to serological evidence of autoimmunity
AU - Zanussi, Carlo
AU - Rugarli, Claudio
AU - Casali, Paolo
AU - Fabio, Giovanna
AU - Perussia, Bice
AU - Sabbadini Villa, Maria Grazia
AU - Scorza Smeraldi, Raffaella
AU - Duca, Giorgio
PY - 1977/4
Y1 - 1977/4
N2 - When a group of 104 aged subjects was screened for autoimmune reactions, positive reactions for the rheumatoid factor and/or autoantibodies (ANA, anti-thyroid, PCA, anti-smooth muscle, anti-mitochondria) were recorded in 40.4%. Immunological functions were studied in 32 positive aged subjects, 32 age- and sex-matched negative controls, and 32 young subjects. Some differences attributable to the process of aging were quite evident, such as a depression in the percentage of E rosette forming peripheral lymphocytes and in their response to PHA, and an increase in the percentage of IgG-bearing peripheral lymphocytes and in the serum levels of IgA and three complement fractions (C'3, C'4 and C'3-PA). No clear-cut picture was noted when autoimmunity-positive and -negative, aged subjects were compared. However, some differences between sexes suggest that autoimmune reactions are linked to a depressed T cell function mainly in males, whereas the reverse is true for females.
AB - When a group of 104 aged subjects was screened for autoimmune reactions, positive reactions for the rheumatoid factor and/or autoantibodies (ANA, anti-thyroid, PCA, anti-smooth muscle, anti-mitochondria) were recorded in 40.4%. Immunological functions were studied in 32 positive aged subjects, 32 age- and sex-matched negative controls, and 32 young subjects. Some differences attributable to the process of aging were quite evident, such as a depression in the percentage of E rosette forming peripheral lymphocytes and in their response to PHA, and an increase in the percentage of IgG-bearing peripheral lymphocytes and in the serum levels of IgA and three complement fractions (C'3, C'4 and C'3-PA). No clear-cut picture was noted when autoimmunity-positive and -negative, aged subjects were compared. However, some differences between sexes suggest that autoimmune reactions are linked to a depressed T cell function mainly in males, whereas the reverse is true for females.
KW - Aging
KW - Autoantibodies
KW - Autoimmune disease
KW - Autoimmunity
KW - Complement
KW - Immunological functions
KW - Lymphocytes
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U2 - 10.1007/BF02879477
DO - 10.1007/BF02879477
M3 - Article
C2 - 303369
AN - SCOPUS:0017707356
VL - 7
SP - 114
EP - 123
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0390-5748
IS - 2
ER -