Immunologic studies of disseminated infection with Aspergillus fumigatus in the nude mouse

D. M. Williams, Marc H Weiner, D. J. Drutz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Immunity to infection with Aspergillus fumigatus conidia was studied in the athymic nude (nu/nu) mouse. The intratracheal, intravenous, and intraperitoneal routes of infection were used. Nu/nu mice were not significantly more susceptible than their heterozygous (nu/+) littermates. However, only nu/+ animals could be protected by prior immunization and developed positive, A. fumigatus-specific skin tests. Protection could be transferred to nu/nu recipients by immune glass-adherent cells. Thus, immunity to invasive aspergillus infection is multifactorial and depends on a glass-adherent cell population and T-cells.

Original languageEnglish (US)
Pages (from-to)726-733
Number of pages8
JournalJournal of Infectious Diseases
Volume143
Issue number5
StatePublished - 1981
Externally publishedYes

Fingerprint

Aspergillus fumigatus
Nude Mice
Glass
Immunity
Infection
Fungal Spores
Aspergillus
Skin Tests
Immunization
T-Lymphocytes
Population

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Immunologic studies of disseminated infection with Aspergillus fumigatus in the nude mouse. / Williams, D. M.; Weiner, Marc H; Drutz, D. J.

In: Journal of Infectious Diseases, Vol. 143, No. 5, 1981, p. 726-733.

Research output: Contribution to journalArticle

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