Immunologic studies of disseminated infection with aspergillus fumigates in the nude mouse

Dwight M. Williams, Marc H. Weiner, David J. Drutz

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26 Scopus citations

Abstract

Immunity to infection with Aspergillus fumigatus conidia was studied in the athymic nude (nu/nu) mouse. The intratracheal, intravenous, and intraperitoneal routes of infection were used. Nu/nu mice were not significantly more susceptible than their heterozygous (nu/+) littermates. However, only nu/+ animals could be protected by prior immunization and developed positive, A. fumigatus-specific skin tests. Protection could be transferred to nu/nu recipients by immune glass-adherent cells. Thus, immunity to invasive aspergillus infection is multifactorial and depends on a glass-adherent cell population and T-cells.

Original languageEnglish (US)
Pages (from-to)726-733
Number of pages8
JournalJournal of Infectious Diseases
Volume143
Issue number5
DOIs
StatePublished - May 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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