Immunologic function in patients transplanted for severe combined immunodeficiency selectively engrafted with donor T lymphocytes

R. J. O'Reilly, N. Kapoor, M. S. Pollack

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Immunologic function was examined in 11 patients with severe combined immunodeficiency transplanted with marrow or fetal tissues, who developed a restricted form of lymphoid chimerism in which engraftment of donor lymphoid elements was detected only in the T cell fraction. Patients transplanted with unseparated marrow from HLA matched or HLA-haploidentical, HLA-D compatible donors or lectin-separated, E-rosette depleted marrow from HLA haplotype mismatched donors, developed both humoral and cell mediated immunity. Recipients of fully allogeneic fetal liver ± thymus possessed donor T lymphocytes capable of transforming and producing lymphokines in response to antigens in vitro, and initiating antigen specific granulomatous responses and delayed type hypersensitivity in vivo. However, in the absence of homology for HLA determinants between donor T lymphocytes and host B lymphocytes, antibody responses could not be elicited. These studies suggest that in man, as in rodent species, immunologic reconstitution may be partially restricted in fully allogeneic chimeras.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalBehring Institute Mitteilungen
VolumeNo. 70
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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