Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital

Jane Howard Dees; Larry Dean Coe; Yukio Yasukochi; Bettie Sue Masters

doi:10.1126/science.6770464

Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital

Jane Howard Dees, Larry Dean Coe, Yukio Yasukochi, Bettie Sue Masters

Biochemistry & Structural Biology

Research output: Contribution to journal › Article › peer-review

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Abstract

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.

Original language	English (US)
Pages (from-to)	1473-1475
Number of pages	3
Journal	Science
Volume	208
Issue number	4451
DOIs	https://doi.org/10.1126/science.6770464
State	Published - Jan 1 1980

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abstract = "The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.",

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AU - Masters, Bettie Sue

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AB - The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.

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Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital

Abstract

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