Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital

Jane Howard Dees, Larry Dean Coe, Yukio Yasukochi, Bettie Sue Masters

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.

Original languageEnglish (US)
Pages (from-to)1473-1475
Number of pages3
JournalScience
Volume208
Issue number4451
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General

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