Immunodeficiency potentiates the ability of decellularized muscle matrix to regenerate a volumetric muscle injury

Lucas C. Olson, David J. Cohen, Barbara D. Boyan, Zvi Schwartz, Michael J. McClure

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Volumetric muscle loss (VML) is the abrupt loss of skeletal muscle caused by blast, contusion, laceration, or tumor resection. VML injuries result in extensive scar formation and permanent loss of function. Current strategies to repair VML include autologous muscle transfers and physical therapy. Despite cosmetic improvements, muscle function is not regained. Animal models of VML are crucial in the development of novel strategies that recover muscle function. While athymic animals are often used to prevent immune rejection in cases where xenogeneic components are incorporated, reports indicate that T-cell deficiency in these animals suppresses inflammation, improving regeneration compared to immunocompetent controls. Furthermore, those T-cell deficient animals expressed a different composition of macrophage subtypes, which could contribute to altered regeneration (Grabowska et. al). We hypothesized that repair of a VML defect with an allogeneic decellularized muscle matrix (DMM) would lead to better structural and functional regeneration in athymic rats when compared to immunocompetent rats.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Olson, L. C., Cohen, D. J., Boyan, B. D., Schwartz, Z., & McClure, M. J. (2019). Immunodeficiency potentiates the ability of decellularized muscle matrix to regenerate a volumetric muscle injury. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.