Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide

I. M. Thompson; C. R. Spence; D. L. Lamm; N. R. Diluzio

doi:10.1097/00000441-198711000-00002

Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide

I. M. Thompson, C. R. Spence, D. L. Lamm, N. R. Diluzio

Mays Cancer Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.

Original language	English (US)
Pages (from-to)	294-300
Number of pages	7
Journal	American Journal of the Medical Sciences
Volume	294
Issue number	5
DOIs	https://doi.org/10.1097/00000441-198711000-00002
State	Published - Jan 1 1987

ASJC Scopus subject areas

Medicine(all)

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title = "Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide",

abstract = "Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.",

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AU - Spence, C. R.

AU - Lamm, D. L.

AU - Diluzio, N. R.

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AB - Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.

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