Abstract
Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 294-300 |
| Number of pages | 7 |
| Journal | American Journal of the Medical Sciences |
| Volume | 294 |
| Issue number | 5 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide. / Thompson, I. M.; Spence, C. R.; Lamm, D. L.; Diluzio, N. R.
In: American Journal of the Medical Sciences, Vol. 294, No. 5, 1987, p. 294-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide
AU - Thompson, I. M.
AU - Spence, C. R.
AU - Lamm, D. L.
AU - Diluzio, N. R.
PY - 1987
Y1 - 1987
N2 - Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.
AB - Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.
UR - http://www.scopus.com/inward/record.url?scp=0023619601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023619601&partnerID=8YFLogxK
M3 - Article
C2 - 3425579
AN - SCOPUS:0023619601
VL - 294
SP - 294
EP - 300
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 5
ER -