Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells

D. A. Croix, N. K. Samples, J. L. Vandeberg, W. H. Stone

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A study of the humoral immune response of a marsupial, Monodelphis domestica, was performed using sheep red blood cells as the immunogen and a hemolytic titration as the assay. The primary response to a single intramuscular injection was similar to that observed in other mammalian species, except that the titers remained high for as long as 37 weeks after the initial injection. The secondary response was weaker than the primary response and diminished as early as 15 weeks after the initial injection (and only 11 weeks after the single booster injection). The hyperimmune response was similar to the secondary response, except that the titers remained consistent for up to 10 weeks and then fell to very low levels at 35 weeks. The data support the view that the primary humoral response of this marsupial is similar to that of eutherian mammals. However, the secondary and hyperimmune responses appear to be very weak, if present at all.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalDevelopmental and Comparative Immunology
Volume13
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Monodelphis
Marsupialia
Sheep
Erythrocytes
Injections
Complement Hemolytic Activity Assay
Intramuscular Injections
Humoral Immunity
Mammals

Keywords

  • Humoral immunity
  • Immune response
  • Marsupial

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells. / Croix, D. A.; Samples, N. K.; Vandeberg, J. L.; Stone, W. H.

In: Developmental and Comparative Immunology, Vol. 13, No. 1, 1989, p. 73-78.

Research output: Contribution to journalArticle

Croix, D. A. ; Samples, N. K. ; Vandeberg, J. L. ; Stone, W. H. / Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells. In: Developmental and Comparative Immunology. 1989 ; Vol. 13, No. 1. pp. 73-78.
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