Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor α blocker adalimumab in cryptococcal pneumonia

Jose Cadena; George R. Thompson; Tony T. Ho; Edward Medina; Darrel W. Hughes; Thomas F. Patterson

doi:10.1016/j.diagmicrobio.2009.03.019

Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor α blocker adalimumab in cryptococcal pneumonia

Jose Cadena
, George R. Thompson
, Tony T. Ho
, Edward Medina
, Darrel W. Hughes
, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Tumor necrosis factor α antagonists have proven efficacious for a variety of autoimmune-mediated diseases. However, recent data have highlighted the risk of invasive fungal infections with their use. These agents are typically discontinued when infectious complications occur during therapy; however, the immune reconstitution inflammatory syndrome (IRIS) may be seen after drug cessation. We describe the 1st case of IRIS secondary to cryptococcal pneumonia after cessation of adalimumab.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.03.019
State	Published - Jul 2009

Keywords

Adalimumab
Cryptococcus
Immune reconstitution
TNF-α inhibitors

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2009.03.019

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title = "Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor α blocker adalimumab in cryptococcal pneumonia",

abstract = "Tumor necrosis factor α antagonists have proven efficacious for a variety of autoimmune-mediated diseases. However, recent data have highlighted the risk of invasive fungal infections with their use. These agents are typically discontinued when infectious complications occur during therapy; however, the immune reconstitution inflammatory syndrome (IRIS) may be seen after drug cessation. We describe the 1st case of IRIS secondary to cryptococcal pneumonia after cessation of adalimumab.",

keywords = "Adalimumab, Cryptococcus, Immune reconstitution, TNF-α inhibitors",

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AU - Cadena, Jose

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AU - Ho, Tony T.

AU - Medina, Edward

AU - Hughes, Darrel W.

AU - Patterson, Thomas F.

PY - 2009/7

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AB - Tumor necrosis factor α antagonists have proven efficacious for a variety of autoimmune-mediated diseases. However, recent data have highlighted the risk of invasive fungal infections with their use. These agents are typically discontinued when infectious complications occur during therapy; however, the immune reconstitution inflammatory syndrome (IRIS) may be seen after drug cessation. We describe the 1st case of IRIS secondary to cryptococcal pneumonia after cessation of adalimumab.

KW - Adalimumab

KW - Cryptococcus

KW - Immune reconstitution

KW - TNF-α inhibitors

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Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor α blocker adalimumab in cryptococcal pneumonia

Abstract

Keywords

ASJC Scopus subject areas

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