Immune complexes in sjögren's syndrome

Michael Fischbach; Devron Char; Mary Christensen; Troy Daniels; Keith Whaley; Margaret Alspaugh; Norman Talal

doi:10.1002/art.1780230703

Immune complexes in sjögren's syndrome

Michael Fischbach, Devron Char, Mary Christensen, Troy Daniels, Keith Whaley, Margaret Alspaugh, Norman Talal

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Sera from 48 patients with Sjögren's syndrome were examined for immune complexes by the Raji cell assay. There was no correlation between levels of immune complexes and the degree of lymphocytic infiltration of the labial salivary glands. Serum complement levels were normal. Five patients were serially followed during the development of pseudolymphoma or malignant lymphoma. Immune complex levels in 4 of the 5 patients were generally unchanged throughout the illness and did not parallel disease activity, rheumatoid factor, or SS‐A and SS‐B concentrations. Possible roles for immune complexes in Sjögren's syndrome are discussed.

Original language	English (US)
Pages (from-to)	791-795
Number of pages	5
Journal	Arthritis & Rheumatism
Volume	23
Issue number	7
DOIs	https://doi.org/10.1002/art.1780230703
State	Published - Jul 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780230703

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abstract = "Sera from 48 patients with Sj{\"o}gren's syndrome were examined for immune complexes by the Raji cell assay. There was no correlation between levels of immune complexes and the degree of lymphocytic infiltration of the labial salivary glands. Serum complement levels were normal. Five patients were serially followed during the development of pseudolymphoma or malignant lymphoma. Immune complex levels in 4 of the 5 patients were generally unchanged throughout the illness and did not parallel disease activity, rheumatoid factor, or SS‐A and SS‐B concentrations. Possible roles for immune complexes in Sj{\"o}gren's syndrome are discussed.",

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AU - Fischbach, Michael

AU - Char, Devron

AU - Christensen, Mary

AU - Daniels, Troy

AU - Whaley, Keith

AU - Alspaugh, Margaret

AU - Talal, Norman

PY - 1980/7

Y1 - 1980/7

N2 - Sera from 48 patients with Sjögren's syndrome were examined for immune complexes by the Raji cell assay. There was no correlation between levels of immune complexes and the degree of lymphocytic infiltration of the labial salivary glands. Serum complement levels were normal. Five patients were serially followed during the development of pseudolymphoma or malignant lymphoma. Immune complex levels in 4 of the 5 patients were generally unchanged throughout the illness and did not parallel disease activity, rheumatoid factor, or SS‐A and SS‐B concentrations. Possible roles for immune complexes in Sjögren's syndrome are discussed.

AB - Sera from 48 patients with Sjögren's syndrome were examined for immune complexes by the Raji cell assay. There was no correlation between levels of immune complexes and the degree of lymphocytic infiltration of the labial salivary glands. Serum complement levels were normal. Five patients were serially followed during the development of pseudolymphoma or malignant lymphoma. Immune complex levels in 4 of the 5 patients were generally unchanged throughout the illness and did not parallel disease activity, rheumatoid factor, or SS‐A and SS‐B concentrations. Possible roles for immune complexes in Sjögren's syndrome are discussed.

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Immune complexes in sjögren's syndrome

Abstract

ASJC Scopus subject areas

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