Immune Cell Metabolism in Systemic Lupus Erythematosus

Seung Chul Choi, Anton A. Titov, Ramya Sivakumar, Wei Li, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Cellular metabolism represents a newly identified checkpoint of effector functions in the immune system. A solid body of work has characterized the metabolic requirements of normal T cells during activation and differentiation into polarized effector subsets. Similar studies have been initiated to characterize the metabolic requirements for B cells and myeloid cells. Only a few studies though have characterized the metabolism of immune cells in the context of autoimmune diseases. Here, we review what is known on the altered metabolic patterns of CD4+ T cells, B cells, and myeloid cells in lupus patients and lupus-prone mice and how they contribute to lupus pathogenesis. We also discuss how defects in immune metabolism in lupus can be targeted therapeutically.

Original languageEnglish (US)
Article number66
JournalCurrent rheumatology reports
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • Autoimmunity
  • B cells
  • Immunometabolism
  • Lupus
  • Myeloid cells
  • T cells
  • Therapeutic targets

ASJC Scopus subject areas

  • Rheumatology

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