Abstract
Cellular metabolism represents a newly identified checkpoint of effector functions in the immune system. A solid body of work has characterized the metabolic requirements of normal T cells during activation and differentiation into polarized effector subsets. Similar studies have been initiated to characterize the metabolic requirements for B cells and myeloid cells. Only a few studies though have characterized the metabolism of immune cells in the context of autoimmune diseases. Here, we review what is known on the altered metabolic patterns of CD4+ T cells, B cells, and myeloid cells in lupus patients and lupus-prone mice and how they contribute to lupus pathogenesis. We also discuss how defects in immune metabolism in lupus can be targeted therapeutically.
Original language | English (US) |
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Article number | 66 |
Journal | Current rheumatology reports |
Volume | 18 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2016 |
Externally published | Yes |
Keywords
- Autoimmunity
- B cells
- Immunometabolism
- Lupus
- Myeloid cells
- T cells
- Therapeutic targets
ASJC Scopus subject areas
- Rheumatology