Immune-based therapies for traumatic brain injury: Insights from pre-clinical studies

Caroline Amaral Machado, Ana Cristina Simões E. Silva, Amanda Silva de Miranda, Thiago Macedo E. Cordeiro, Rodrigo Novaes Ferreira, Leonardo Cruz de Souza, Antônio Lúcio Teixeira, Aline Silva de Miranda

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Traumatic Brain Injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI-associated outcomes. Therefore, the search for effective therapies is a priority goal. In this context, animal models have become valuable tools to study molecular and cellular mechanisms involved in TBI pathogenesis as well as novel treatments. Herein, we discuss therapeutic strategies to treat TBI focused on immunomodulatory and/or anti-inflammatory approaches in the pre-clinical setting.

Original languageEnglish (US)
Pages (from-to)5374-5402
Number of pages29
JournalCurrent Medicinal Chemistry
Volume27
Issue number32
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Immunomodulatory agents
  • Inflammation
  • Pathogenesis
  • Traumatic brain injury
  • Treatment

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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