Abstract
Objective: To characterize imatinib's effect on endometrial stromal cell (ESC) attachment, proliferation, and invasion in modeled peritoneum. Design: In vitro study. Setting: Academic medical center. Patient(s): Twelve normally cycling women. Intervention(s): Imatinib treatment in ESCs from women without endometriosis. Main Outcome Measure(s): Rate of ESC attachment, proliferation, and invasion. Result(s): Imatinib treatment at 10 μM had no effect on ESC attachment. Treatment with 0.5 μM, 2 μM, and 10 μM of imatinib reduced ESC proliferation by 30%, 72%, and 76%, respectively. The 0.1 μM dose of imatinib had no effect on proliferation. Treatment with 5 μM and 10 μM of imatinib reduced ESC invasion by 30% and 73%, respectively. The 2 μM dose had no effect on invasion. Conclusion(s): Imatinib treatment reduces ESC proliferation and invasion in modeled peritoneum without altering attachment. Imatinib may have a therapeutic role in endometriosis treatment.
Original language | English (US) |
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Pages (from-to) | 2531-2535 |
Number of pages | 5 |
Journal | Fertility and sterility |
Volume | 94 |
Issue number | 7 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Endometriosis
- imatinib
- modeled peritoneum
- tyrosine kinase inhibitor
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology