Imaging of abdominal and pelvic manifestations of graft-versus-host disease after hematopoietic stem cell transplant

Meghan G. Lubner, Christine O. Menias, Michelle Agrons, Kinan Alhalabi, Venkata S. Katabathina, Khaled M. Elsayes, Perry J. Pickhardt

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

OBJECTIVE. Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant (HSCT). GVHD predominantly affects the skin, gastrointestinal system and hepatobiliary systems. Imaging findings in the gastrointestinal tract include bowel wall thickening with mucosal enhancement, mesenteric edema, and vascular engorgement. In the hepatobiliary system, hepatosplenomegaly, periportal edema, bile duct dilatation, and gallbladder and biliary wall thickening are seen. Although the imaging findings of GVHD are nonspecific, with a known history of HSCT, GVHD should be considered. CONCLUSION. GVHD is a serious complication of HSCT, which involves multiple organ systems, with imaging manifestations most commonly seen in the gastrointestinal tract and hepatobiliary system. Knowledge of the imaging manifestations of GVHD, which alone may be relatively nonspecific, taken in conjunction with clinical history including the timing and type of HSCT, laboratory values, stool studies, and dermatologic findings can increase radiologist confidence in suggesting this diagnosis.

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalAmerican Journal of Roentgenology
Volume209
Issue number1
DOIs
StatePublished - Jul 2017

Keywords

  • Gastrointestinal
  • Graft-versus-host disease
  • Hematopoietic stem cell transplant
  • Hepatobiliary

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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