Imaging features of primary immunodeficiency disorders

Jose A. Rodriguez, Tami J. Bang, Carlos S. Restrepo, Daniel B. Green, Lorna P. Browne, Daniel Vargas

Research output: Contribution to journalArticlepeer-review

Abstract

Primary immunodeficiency disorders (PIDs), which are humoral, combined, and innate defects of the immune system, are relatively uncommon and may go undiagnosed in patients experiencing recurrent infections, resulting in increased morbidity and mortality. PIDs are clinically characterized by a broad spectrum of disorders, including repeated infections, autoimmune disorders, lymphopro-liferative diseases, congenital anomalies, and increased risk of malignancy. Cardiothoracic imaging plays a crucial role in the diagnosis of PIDs owing to the high rates of repeated respiratory infections leading to bronchiectasis and other forms of chronic lung disease. Although PIDs as a group may seem similar in terms of radiologic features and clinical manifestations, there are specific entities that are pertinent to each PID on an individual level. For example, patients with common variable immunodeficiency may develop a unique granulomatous lymphocytic interstitial lung disease, and Good syndrome is associated with thymoma. Familiarity with the imaging characteristics of these disorders may expedite diagnosis and prognostication, and better direct therapy. Reviewing the thoracic manifestations of all PIDs is beyond the scope of this article; thus, the focus herein is on discussing the thoracic manifestations of the most common PIDs and their imaging features.

Original languageEnglish (US)
Article numbere200418
JournalRadiology: Cardiothoracic Imaging
Volume3
Issue number2
DOIs
StatePublished - Apr 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Imaging features of primary immunodeficiency disorders'. Together they form a unique fingerprint.

Cite this