Iloprost in embolic renal failure

Tal Grenader, Meyer Lifschitz, Linda Shavit

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Cholesterol embolism is a serious disease with a high morbidity and mortality rate. There is no clear evidence that any specific treatment helps this syndrome. We report a patient who developed acute renal failure due to cholesterol crystal embolism following percutaneous transluminal angioplasty of a renal artery. Treatment with iloprost for peripheral symptoms of cholesterol emboli resulted in rapid resolution of toe cyanosis, decrease in leg pain and a significant decrease in serum creatinine shortly after initiation of treatment. One month after initiation of iloprost therapy, skin signs of cholesterol emboli disappeared and leg pain diminished. Gradually reduction in serum creatinine level was also observed (from 390 to 160 micromol/L). Eighteen months after the arteriography, the patient had stable renal function with creatinine levels of 150-160 micromol/L, and he was asymptomatic.

Original languageEnglish (US)
Pages (from-to)339-341
Number of pages3
JournalMount Sinai Journal of Medicine
Volume72
Issue number5
StatePublished - 2005
Externally publishedYes

Keywords

  • Acute renal failure
  • Cholesterol crystal emboli
  • Iloprost

ASJC Scopus subject areas

  • Medicine(all)

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