IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I. Up-regulation of muscle IL-15 by IL-4

Sabrina Shandley, Sonia Martinez, Keith Krolick

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The study reported below describes increased expression of IL-4 receptor in cultured rat myocytes following exposure to an antibody reactive with the acetylcholine receptor (AChR). In addition, upon up-regulation of IL-4R, myocytes demonstrated an increased responsiveness to IL-4 by producing increased levels of IL-15. Moreover, following passive transfer of AChR antibody into Lewis rats, both the increased IL-4R expression and IL-15 production were also observed in intact skeletal muscle, co-localizing in particular individual muscle fibers; the same muscle fibers also produced the chemokine MCP-1 to which IL-4-producing T cells were attracted. A model is proposed in which these muscle activities participate in disease progression in experimental myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)246-256
Number of pages11
JournalClinical Immunology
Volume132
Issue number2
DOIs
StatePublished - Aug 2009

Keywords

  • Autoimmune disease
  • Muscle IL-15
  • Muscle IL-4 receptor
  • Muscle disease
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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