IL-10通过抑制IFN-γ和IL-2表达促进鼠衣原体感染

Translated title of the contribution: IL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expression

Qingzhi He, Mengting He, Xin Wang, Xiaoqing Luo, Yimou Wu, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To study the possible molecular mechanism of IL-10 in promoting Chlamydia muridarum infection in mice. Methods: C57BL/6 wild-type and IL-10 gene knockout (IL-10-/-) mice were infected with Chlamydia muridarum. Indirect immunofluorescence assay was used to detect the growth of Chlamydia muridarum in the intestinal and genital tracts. The severity of genital diseases was assessed by hydrosalpinx scoring. Expression of IFN-γ and IL-2 in blood was measured by ELISA. Results: Compared with the wild-type group, Chlamydia clearance in the intestinal and genital tracts of IL-10-/- mice was significantly faster, and the expression of IFN-γ and IL-2 increased significantly. In addition, wild-type mice showed more serious hydrosalpinx. Conclusions: IL-10 delays Chlamydia trachomatis clearance and promotes Chlamydia infection through inhibiting the expression of IFN-γ and IL-2, which aggravates hydrosalpinx.

Translated title of the contributionIL-10 promotes Chlamydia muridarum infection in mice through inhibiting IFN-γ and IL-2 expression
Original languageChinese
Pages (from-to)126-130
Number of pages5
JournalChinese Journal of Microbiology and Immunology (China)
Volume39
Issue number2
DOIs
StatePublished - Feb 28 2019

Keywords

  • Chlamydia trachomatis
  • Cytokine
  • IL-10
  • Immunity

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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