IL-1β Is Involved with the Generation of Pain in Experimental Autoimmune Encephalomyelitis

David Henrique Rodrigues, Bruno Pereira Leles, Vivian Vasconcelos Costa, Aline Silva Miranda, Daniel Cisalpino, Dawidson Assis Gomes, Danielle Glória de Souza, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Pain is one of the main symptoms of multiple sclerosis, a demyelinating disease of the central nervous system that affects millions of people worldwide. The experimental autoimmune encephalomyelitis (EAE) is considered an experimental model of multiple sclerosis, and besides motor weakness, hypernociception is one of the clinical signs of animals with EAE. In this study, we investigated the influence of some cytokines in the generation of the hypernociceptive response in a mouse model of EAE using MOG35–55. We measured some cytokines in the dorsal root ganglia (DRG), an important anatomical structure involved in pain. We found increased levels of the cytokines TNF-α, IL-1β, and Kc in DRGs of animals with EAE. We used the antibody IL-1ra to antagonize the effects of IL-1β, and animals presented a decrease in the hypernociceptive response. Thus, our results suggest that hypernociception in this experimental model of EAE may be a consequence of the increase in some cytokines in DRGs, especially IL-1β.

Original languageEnglish (US)
Pages (from-to)6540-6547
Number of pages8
JournalMolecular Neurobiology
Volume53
Issue number9
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • Cytokines
  • Dorsal root ganglia
  • Experimental autoimmune encephalomyelitis
  • Hypernociception

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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