IL-1β decreases expression of amyloid precursor protein gene in human glioma cells

Funmei Yang, Laila Jansen, William E. Friedrichs, James M. Buchanan, Barbara H. Bowman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called β4, is a characteristic component of senile plaques in brains of affected patients. Efforts to intervene in Alzheimer's disease include approaches by which APP levels can be decreased in brain. The study described here demonstrates the expression of APP gene in four cell lines that originated from human brain glioblastomas. In one line, HTB 17, APP mRNA level was approximately 25% the APP mRNA found in human brain and 150% that found in human liver. To ascertain whether or not APP expression in HTB 17 cells could be modulated by a cytokine associated with the inflammatory response, cells were cultured in the presence of IL-1β. A significant decrease in APP mRNA accompanied treatment of glioma cells with IL-1β.

Original languageEnglish (US)
Pages (from-to)1014-1019
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume191
Issue number3
DOIs
StatePublished - Mar 31 1993

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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