TY - JOUR
T1 - IgG4-related kidney disease
T2 - Clinicopathologic features, differential diagnosis, and mimics
AU - Gilani, Sarwat I.
AU - Buglioni, Alessia
AU - Cornell, Lynn D.
N1 - Publisher Copyright:
© 2023
PY - 2024/3
Y1 - 2024/3
N2 - IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction. While usually associated with other organ involvement by IgG4-RD, kidney-alone involvement is present in approximately 20 % of IgG4-RKD. Compared to IgG4-RD overall, patients with IgG4-RKD are more likely to show increased serum IgG4 or IgG, and more likely to have hypocomplementemia. In this review, we extensively cover other types of autoimmune and plasma cell-rich interstitial nephritis, mass forming inflammatory diseases of the kidney, and other mimics of IgG4-TIN, in particular ANCA-associated disease.
AB - IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction. While usually associated with other organ involvement by IgG4-RD, kidney-alone involvement is present in approximately 20 % of IgG4-RKD. Compared to IgG4-RD overall, patients with IgG4-RKD are more likely to show increased serum IgG4 or IgG, and more likely to have hypocomplementemia. In this review, we extensively cover other types of autoimmune and plasma cell-rich interstitial nephritis, mass forming inflammatory diseases of the kidney, and other mimics of IgG4-TIN, in particular ANCA-associated disease.
KW - Anti-neutrophil cytoplasmic antibody
KW - Interstitial nephritis
KW - Membranous glomerulonephritis
KW - Membranous nephropathy
KW - Renal biopsy
KW - Tubulointerstitial nephritis
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U2 - 10.1053/j.semdp.2023.12.001
DO - 10.1053/j.semdp.2023.12.001
M3 - Review article
C2 - 38246802
AN - SCOPUS:85183537913
SN - 0740-2570
VL - 41
SP - 88
EP - 94
JO - Seminars in Diagnostic Pathology
JF - Seminars in Diagnostic Pathology
IS - 2
ER -