IGF-I mediated survival pathways in normal and malignant cells

Research output: Contribution to journalReview article

154 Scopus citations


The type-I and -II insulin-like growth factors (IGF-I, II) are now established as survival- or proliferation-factors in many in vitro systems. Of note IGFs provide trophic support for multiple cell types or organ cultures explanted from various species, and delay the onset of programmed cell death (apoptosis) through the mitochondrial (intrinsic pathway) or by antagonizing activation of cytotoxic cytokine signaling (extrinsic pathway). In some instances, IGFs protect against other forms of death such as necrosis or autophagy. The effect of IGFs on cell survival appears to be context specific, being determined both by the cell origin (tissue specific) and the cellular stress that induces loss of cellular viability. In many human cancers, there is a strong association with dysregulated IGF signaling, and this association has been extensively reviewed recently. IGF-regulation is also disrupted in childhood cancers as a consequence of chromosomal translocations. IGFs are implicated also in acute renal failure, traumatic injury to brain tissue, and cardiac disease. This article focuses on the role of IGFs and their cellular signaling pathways that provide survival signals in stressed cells.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number1
StatePublished - Aug 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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