IgE induced blood coagulation alterations in the rabbit: consumption of coagulation factors XII, XI, and IX in vivo

R. N. Pinckard, C. Tanigawa, M. Halonen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Intravenous administration of BSA into 3 month old rabbits producing detectable anti BSA antibody only of the IgE class of immunoglobulin induced a variety of intravascular blood coagulation alterations. The IgE induced blood coagulation alterations observed in the plasma 15 min after antigen challenge included: a) the intravascular consumption of intrinsic blood coagulation factors XII, XI, and IX and possibly the reduction in clottable fibrinogen; b) a significant prolongation of the activated partial thromboplastin time but not the prothrombin time; and c) the production of an inhibitor affecting the last stage of blood coagulation. The observed blood coagulation alterations were not caused by the manipulative procedures utilized, the presence of anti BSA, IgG or IgM antibody, histamine induced alterations in the vascular endothelium or the development of hypotensive shock. It is proposed that specific IgE antibody can induce directly or indirectly the activation of intrinsic blood coagulation in vivo.

Original languageEnglish (US)
Pages (from-to)525-532
Number of pages8
JournalJournal of Immunology
Volume115
Issue number2
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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