Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families

L. Almasy, S. B. Bressman, D. Raymond, P. L. Kramer, P. E. Greene, G. A. Heiman, B. Ford, J. Yount, D. De Leon, S. Chouinard, R. Saunders-Pullman, M. F. Brin, R. P. Kapoor, A. C. Jones, H. Shen, S. Fahn, N. J. Risch, T. G. Nygaard

    Research output: Contribution to journalArticlepeer-review

    151 Scopus citations

    Abstract

    The DYT1 locus on chromosome 9q34 is responsible for most childhood limb-onset idiopathic torsion dystonia (ITD). Linkage to DYT1 has been excluded in families with adult-onset, and predominantly cranial-cervical, ITD. We mapped a locus (DYT6) associated with prominent cranial-cervical ITD in two large Mennonite families to chromosome 8. An identical haplotype spanning 40-cM segregates with ITD in these families, suggesting a shared mutation from the recent past.

    Original languageEnglish (US)
    Pages (from-to)670-673
    Number of pages4
    JournalAnnals of neurology
    Volume42
    Issue number4
    DOIs
    StatePublished - Oct 1997

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

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