Identifying novel therapeutic agents using xenograft models of pediatric cancer

Raushan T. Kurmasheva, Peter J Houghton

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

In the USA, the overall cure rate for all childhood cancers is seventy percent, and in many patients that ultimately fail curative therapy, initial responses to current multimodality treatments (surgery, radiation therapy and chemotherapy) is good, with overall 5-year event-free survival approaching 80 %. However, current approaches to curative therapy result in significant morbidity and long-term sequelae, including cardiac dysfunction and cognitive impairment. Furthermore, dose-intensive chemotherapy with conventional agents has not significantly improved outcomes for patients that present with advanced or metastatic disease. Classical cytotoxic agents remain the backbone for curative therapy of both hematologic and solid tumors of childhood. While ‘molecularly’ targeted agents have shown some clinical activity, responses are often modest and of short duration; hence, there is a need to identify new classes of cytotoxic agent that are effective in patients at relapse and that have reduced or different toxicity profiles to normal tissues. Here we review the pediatric preclinical testing program experience of testing novel agents, and the value and limitations of preclinical xenograft models and genetically engineered mouse models for developing novel agents for treatment of childhood cancer.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalCancer Chemotherapy and Pharmacology
Volume78
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

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Keywords

  • Cytotoxic drugs
  • Human tumor xenografts
  • Pediatric tumor xenografts

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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